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CAS No.: 27854-88-2 | (1R)-1-(4-Pyridinyl)ethanol

CAS No.: 27854-88-2 | (1R)-1-(4-Pyridinyl)ethanol

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Pharmaceutical Intermediates

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Product introduction

Product name: (1R)-1-(4-Pyridinyl)ethanol
Other name: (αR)-α-Methyl-4-pyridinemethanol
CAS number: 27854-88-2
MF: C7H9NO
MW: 123.15
MP: 55-58℃
BP: 239.7±15.0℃
Density: 1.082±0.06g/cm3
MDL No.：MFCD00077865
Purity: 98% min
Appearance: Light brown powder
Storge: Inert atmosphere, Room temperature
Package: 1g/5g/25g/ or as your special request.
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Made in China

Synthesis Route 1 (Yield 98%) 1122-54-9 >> 27854-88-2

With dimethylsulfide borane complex; (2aS,4aR)-2,2-diphenylhexahydro-2H-1,7-dioxa-7b-aza-7a-boracyclopenta[cd]indene In toluene at 20℃; for 1.17 h; Inert atmosphere

Synthesis Route 2 (Yield 88%) 1122-54-9 >> 27854-88-2
Stage #1: With borane*DMS In tetrahydrofuran at 20℃; for 7 h;
Stage #2: With methanol In tetrahydrofuran at 0℃; for 12 h; Heating / reflux

Synthesis Route 3 (Yield 85%) 1122-54-9 >> 27854-88-2
Stage #1: With borane*DMS In tetrahydrofuran
Stage #2: With methanol In tetrahydrofuran at 0℃; for 4 h; Heating / reflux

Reference:
[1] Organic Letters, 2017, vol. 19, # 3, p. 690 - 693
[2] Advanced Synthesis and Catalysis, 2014, vol. 356, # 10, p. 2293 - 2302
[3] Tetrahedron Letters, 2016, vol. 57, # 23, p. 2492 - 2495
[4] Synlett, 1997, vol. 1997, # 3, p. 273 - 274
[5] Synthesis, 2009, # 14, p. 2413 - 2417

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